Tetrahydrobiopterin and Related Biologically Important Pterins

摘要: Some naturally occurring pteridine derivatives carry out various important metabolic transformations which produce and metabolize essential materials for life as cofactors in all kinds of living organisms. For example, the work biosyntheses amino acids, nucleic neurotransmitters nitrogen monoxides metabolisms purine aromatic acids human body. Based on mechanisms metabolisms, such compounds have long been interested biological chemistry medicinal chemistry. are practically used chemotherapy or diagnosis diseases. In Sect. 1, we briefly review history significances other than tetrahydrobiopterin, e.g., folic acid, molybdenum cofactor. Recent progress analysis synthesis tetrahydrobiopterin its analogues is summarized Sects 2 3. Sects. 4 5, The biosynthesis functions catecholamine NO described 6 describes diseases caused by deficiency tetrahydrobiopterin.