Clinical Efficacy and Pharmacokinetics of Antimony in Cutaneous Leishmaniasis Patients Treated With Sodium Stibogluconate

摘要: The efficacy and pharmacokinetics of antimony were explored in 12 young male patients with cutaneous leishmaniasis following intramuscular administration sodium stibogluconate equivalent to 600 mg (Sb). Patients' cure rate was evaluated up 6 weeks after treatment. Blood samples collected at different time periods on the first last days a 3-week Twenty-four-hour urine also both occasions for estimation renal clearance (CL r ). blood concentrations Sb profile best described by 2-compartment model first-order absorption rate. mean half-life 0. 21 ± 0.023 0.36 0.18 hours doses, respectively. A rapid distribution phase followed slower elimination 9.4 1 .9 9 . 2.3 days, An accumulation index 2.33 calculated. fraction dose excreted 0.386 0.11 0.326 0.05 occasions, CL vvas 4.88 1.13 4.58 1.05 L/h. In current study, all completely healed week end treatment, as judged treating physician. conclusion, seems be multicompartmental nature.