Dichotocejpins A-C: New Diketopiperazines from a Deep-Sea-Derived Fungus Dichotomomyces cejpii FS110.
作者： Zhen Fan , Zhang-Hua Sun , Zhong Liu , Yu-Chan Chen , Hong-Xin Liu
DOI: 10.3390/MD14090164
关键词:
摘要: Three new diketopiperazines, dichotocejpins A–C (1–3), together with eight known analogues (4–11), were isolated from the culture of deep-sea sediment derived fungus Dichotomomyces cejpii FS110. Their structures, including absolute configurations, elucidated by a combination HRESIMS, NMR, X-ray crystallography, and ECD calculations. Compounds 4–6, 10–11 showed significant cytotoxic activities against MCF-7, NCI-H460, HepG-2, SF-268 tumor cell lines. Compound 1 exhibited excellent inhibitory activity α-glucosidase an IC50 138 μM.
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