Effect of Hydrophilic Polymers on Physical Stability of Liposome Dispersions

摘要: Interactions between various hydrophilic polymers and liposomes composed of hydrogenated soybean lecithin were investigated by means isothermal titration calorimetry (ITC), FT-IR, dynamic light scattering (DLS) measurements. Their effect on the dispersity was turbidity measurement. Sodium alginate found to bind lipid bilayers via electrostatic interaction stabilize over a wide concentration range despite its high hydrophilicity. This elucidated in terms irreversible adsorption sodium onto liposome surfaces. Carboxymethyl cellulose salt poly(vinyl alcohol) gave similar results, but stabilization reduced. Other polymers, which adsorbed surfaces very weakly or not at all, destabilized significantly, just below overlap polymers. interpreted depletion flocculation. The liposo...