Effects of topically administered ouabain on aqueous humor dynamics

摘要: Repeated topical administration of ouabain has been shown to induce a hypodynamic state in both normal and buphthalmic rabbit eyes. The fall intraocular pressure is greater with increasing concentrations ouabain. When 0·25% or 0·125% solutions are used on rabbits, lowering the observed within 2 hr. This effect persists for about 3 days. Responsiveness does not appear reduced when tests repeated frequently same animal. histological evidence eyes suggests that elevated these most likely related deficient drainage mechanism by drug such as due, primarily, an inhibition aqueous humor secretion.