Correlating interleukin-10 promoter gene polymorphisms with human cerebral infarction onset.

摘要: Evidence suggests that interleukin-10 (IL-10) deficiency exacerbates inflammation and worsens the outcome of brain ischemia. In view critical role single nucleotide polymorphic sites -1082 (A/G) -819 (C/T) in promoter region IL-10 gene, we hypothesized they are associated with cerebral infarction morbidity Chinese Han population. We genotyped these allelic gene polymorphisms by amplification refractory mutation system-polymerase chain reaction methods 181 patients (cerebral group) 115 healthy subjects (control group). identified significant differences genotype distribution allele frequency IL-10-1082 A/G between control groups (χ (2) = 6.643, P 0.010). The A was significantly higher group (92.3%) than (86.1%) (P 0.015). Moreover, risk AA 2-fold AG (OR 2.031, 95%CI: 1.134-3.637). addition, together hypertension independent factor 2.073, 1.278-3.364). No statistical difference or IL-10-819 C/T found > 0.05). These findings suggest polymorphism is involved infarction, increased closely occurrence infarction.