The replication of the association of the rs6832151 within chromosomal band 4p14 with Graves' disease in a Polish Caucasian population
作者： K. Szymański , T. Bednarczuk , P. Krajewski , R. Płoski
DOI: 10.1111/J.1399-0039.2012.01854.X
关键词:
摘要: Recently Chu et al. conducted a genome-wide association study in Chinese Han population and identified two novel Graves' disease (GD) susceptibility loci within 4p14 (rs6832151) 6q27 (rs9355610). Our purpose was to replicate these associations Polish Caucasian population. We analyzed rs6832151 rs9355610 genotypes case-control based on 560 GD patients 1475 unrelated controls using TaqMan assays. had the power of 0.8 0.6 detect effects originally reported for rs9355610, respectively. found an between G allele (odds ratio OR = 1.27, P 0.002). Analysis model inheritance suggested that dominant should be preferred (P(fit) 0.938, 1.39, 0.001). For formally significant effect observed assuming recessive (OR 1.24, 0.028), whereas analysis distribution showed trend 1.14,95%, 0.082). findings are first show possibly contribute pathogenesis also Caucasians.
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