Idiotypic immunization induces immunity to mutated p53 and tumor rejection.

摘要: The p53 molecule might serve as a common tumor-associated antigen, the tumor suppressor gene is mutated and protein often over-expressed in cells. We report that effective immunity to can be induced through an idiotypic network by immunization of mice with monoclonal antibody (PAb-240) specific for p53, or peptide derived from complementarity determining region (CDR) 3 variable domain light chain (VL) this antibody. immunized produced IgG antibodies mounted cytotoxic reaction line bearing p53. idiotypically were resistant challenge Thus immunogens activating resistance some tumors. At basic level, these findings indicate may organized naturally within immune system.