Parsing Schizophrenia with Neurocognitive Tests: Evidence of Stability and Validity

摘要: The stability and validity of a neurocognitive typology for schizophrenia were studied in 55 chronic patients who met DSMIII-R criteria the illness. Subtypes based on an earlier cluster analytic study by Heinrichs Awad (1993) that utilized following variables: IQ (WAIS-R), categories (Wisconsin Card Sorting Test), free recall intrusions (California Verbal Learning bilateral motor performance (Purdue Pegboard). Stability was examined analyzing subtype assignment at original assessment 3 years later follow-up. over this interval variable with overall kappa .45 individual kappas from .12 to .66. Adjunct cognitive clinical data gathered follow-up provide evidence several subtypes, especially terms their functional differences. There no symptom differences relatively asymptomatic medicated sample patients. results are discussed possibility patterns dysfunction may underlie schizophrenia, implications understanding heterogeneity illness its outcomes.