The mechanisms of alloxan- and streptozotocin-induced diabetes.

作者: S. Lenzen

DOI: 10.1007/S00125-007-0886-7

关键词:

摘要: … Alloxan and streptozotocin are toxic glucose analogues that … Following its uptake into the beta cells, streptozotocin is split into … , also explains how streptozotocin is able to inhibit glucose-…

参考文章(101)
Lars Hammarstr�m, Bo Hellman, Sven Ullberg, On the accumulation of alloxan in the pancreatic β-cells Diabetologia. ,vol. 3, pp. 340- 345 ,(1967) , 10.1007/BF00429866
John W. Patterson, Arnold. Lazarow, Stanley. Levey, Alloxan and dialuric acid; their stabilities and ultraviolet absorption spectra. Journal of Biological Chemistry. ,vol. 177, pp. 187- 196 ,(1949) , 10.1016/S0021-9258(18)57074-5
R B Weiss, Streptozocin: a review of its pharmacology, efficacy, and toxicity. Cancer treatment reports. ,vol. 66, pp. 427- 438 ,(1982)
Sigurd Lenzen, Markus Tiedge, Anne Jörns, Rex Munday, Alloxan derivatives as a tool for the elucidation of the mechanism of the diabetogenic action of alloxan Birkhäuser Boston. pp. 113- 122 ,(1996) , 10.1007/978-1-4612-4112-6_8
Anne Pomeroy Autor, Pathology of oxygen Academic Press. ,(1982)
Eleazar Shafrir, Lessons from Animal Diabetes ,(1984)
N Rakieten, M R Nadkarni, M L Rakieten, Studies on the diabetogenic action of streptozotocin (NSC-37917). Cancer chemotherapy reports. ,vol. 29, pp. 91- 98 ,(1963)
Christine C. Winterbourn, William B. Cowden, Harry C. Sutton, Auto-oxidation of dialuric acid, divicine and isouramil. Superoxide dependent and independent mechanisms. Biochemical Pharmacology. ,vol. 38, pp. 611- 618 ,(1989) , 10.1016/0006-2952(89)90206-2
Volker Burkart, Zhao-Qi Wang, Jürgen Radons, Birgit Heller, Zdenko Herceg, Laura Stingl, Erwin F Wagner, Hubert Kolb, None, Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin. Nature Medicine. ,vol. 5, pp. 314- 319 ,(1999) , 10.1038/6535