Pulsatile Hormone Secretion: Mechanisms, Significance and Evaluation

摘要: Secretion of anterior and posterior pituitary hormones, adrenal glucocorticoids, mineralocorticoids catecholamines, gonadal sex steroids, parathormone, insulin glucagon is pulsatile (burst-like or episodic). Neuronal inputs, cellular excitability feedback with time delays constitute proximate mechanisms driving recurrent pulses. Both the amplitude frequency gonadotropin, thyrotropin, prolactin sex-steroid pulses determine their mean concentrations. In contradistinction, primarily growth hormone, adrenocorticotropin, cortisol, parathormone controls average values. Gonadotropin-releasing hormone growth-hormone convey unique signaling information to target tissues. Evaluation that govern secretion requires simultaneous quantification number, size shape secretory bursts, underlying nonpulsatile (basal) associated elimination kinetics. The necessary methodology termed deconvolution analysis. More complex ensemble models are used interlink neurohormone signals by estimating endogenous dose-response curves noninvasively. approximate entropy statistic a specific sensitive measure fidelity within an system, Implications pulsatility include regulation somatic growth, reproduction, muscle bone mass, visceral fat burden, glucose metabolism, parturition, sodium water balance.