Simultaneous measurements of temperature and pH in vivo using NMR in conjunction with TmDOTP5

摘要: NMR techniques for temperature and pH measurements have attracted increasing interest in recent years, motivated part by the growing importance of medical hyperthermia treatment cancer. The chemical shifts thulium 1, 4, 7, 10-tetraazacyclododecane-1, 10-tetrakis(methylene phosphonate) (TmDOTP5−) been studied as a function pH. results demonstrate that TmDOTP5− resonance are highly sensitive to (∼1.0 ppm/°C) (∼3.2 ppm/pH unit) at clinically relevant field strengths. A new method is presented which utilizes two magnetically non-equivalent protons simultaneous both difference shift values pairs 1H resonances provides sensitivity about 1.6 ppm/°C. technique demonstrated live rats undergoing ultrasound-induced therapy. Copyright © 2000 John Wiley & Sons, Ltd. Abbreviations used: CSI chemical imaging TmDOTP5− thulium