Tumoral platinum concentrations in patients treated with repeated low-dose cisplatin as a radiosensitizer

摘要: The aim of the present study was to check whether platinum (Pt) concentrations achieved in tumors with a daily low-dose schedule were close those promoting radiosensitization. Fifteen previously untreated patients histologically proven advanced uterine cervix studied. They received irradiation 30 min after short infusion 5 mg cisplatin for consecutive days every week. A biopsy taken from accessible tumor mass, 4 6 hr injection. Blood samples obtained once week, just before injection (H0) and (H30). Quantificative analysis Pt performed by atomic absorption spectrophotometry. Plasma tumoral exhibited marked intersubject variability. median concentration 1,710 mg/g. Median total ultrafiltrable plasma at H0 H30 231 360 ng/ml, 7 90 ng/ml respectively. Tumoral significantly increased during course treatment. Present data show that this CDDP are range shown promote radiosensitization (2,000 ng/g). These results suggest regimen might be started higher doses order reach earlier radiosensitizing concentrations.