作者: Edward N. Ehrlich , Kathleen Lugibihl , Richard L. Landau
DOI: 10.1016/0026-0495(64)90046-0
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摘要: Abstract Aminopyrine was anabolic when administered to 5 normal, young male subjects in usual therapeutic dosages, as indicated by diminished urinary nitrogen, creatine and inorganic phosphorus. The effect with the dosages of aminopyrine employed this study slightly less than but comparable magnitude that resulting from intramuscular administration 25 mg. daily testosterone propionate. In 1 anticipated catabolic influence progesterone partially offset simultaneous oral aminopyrine. Although upon electrolyte metabolism variable, a weak sodium retaining suggested occurrence retention during treatment moderate natriuresis every instance after discontinued. is highly effective analgesic, antipyretic agent which has virtually been discarded armamentarium because frequency agranulocytosis associated its administration. Renewed interest or congeners clinical pharmacologists might be warranted on basis property noted study.