Potential chemotherapeutic targets for Japanese encephalitis: current status of antiviral drug development and future challenges.

摘要: Introduction: Japanese encephalitis (JE) remains a public health threat in Asia. Although several vaccines have been licensed, ∼ 67,900 cases of the disease are estimated to occur annually, probably because vaccine coverage is low. Therefore, effective antiviral drugs required control JE. However, no licensed anti-JE available, despite extensive efforts develop them.Areas covered: We provide general overview JE and virus, including its transmission cycle, distribution, structure, replication machinery, immune evasion mechanisms vaccines. The current situation drug development then reviewed future perspectives discussed.Expert opinion: an urgent issue, only supportive care currently available. Recent progress our understanding viral machinery strategies has identified new targets for development. To date, most candidate b...