Primary phospholipase C and brain disorders
作者： Yong Ryoul Yang , Du-Seock Kang , Cheol Lee , Heon Seok , Matilde Y. Follo
DOI: 10.1016/J.JBIOR.2015.11.003
关键词:
摘要: In the brain, primary phospholipase C (PLC) proteins, PLCβ, and PLCγ, are activated primarily by neurotransmitters, neurotrophic factors, hormones through G protein-coupled receptors (GPCRs) receptor tyrosine kinases (RTKs). Among PLC isozymes, PLCβ1, PLCβ4, PLCγ1 highly expressed differentially distributed, suggesting a specific role for each subtype in different regions of brain. Primary PLCs control neuronal activity, which is important synapse function development. addition, dysregulation signaling linked to several brain disorders including epilepsy, schizophrenia, bipolar disorder, Huntington's disease, depression Alzheimer's disease. this review, we included current knowledge regarding roles isozymes disorders.
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