Consideration of Ketogenic Metabolic Therapy as a Complementary or Alternative Approach for Managing Breast Cancer.

摘要: Breast cancer remains as a significant cause of morbidity and mortality in women. Ultrastructural biochemical evidence from breast biopsy tissue cells shows mitochondrial abnormalities that are incompatible with energy production through oxidative phosphorylation (OxPhos). Consequently, cancer, like most cancers, will become more reliant on substrate level (fermentation) than (OxPhos) for growth consistent the metabolic theory cancer. Glucose glutamine prime fermentable fuels underlie therapy resistance drive (SLP) both cytoplasm (Warburg effect) mitochondria (Q-effect), respectively. Emerging indicates ketogenic (KMT) can reduce glucose availability to tumor while simultaneously elevating ketone bodies, non-fermentable fuel. It is suggested KMT would be effective when used together targeting. Information reviewed suggesting how could systemic inflammation target without causing damage normal cells. Implementation clinic improve progression free overall survival patients