High-cost, high-capacity backbone for global brain communication

作者: Martijn P Van Den Heuvel , René S Kahn , Joaquín Goñi , Olaf Sporns

DOI: 10.1073/PNAS.1203593109

关键词:

摘要: Network studies of human brain structural connectivity have identified a specific set regions that are both highly connected and central. Recent analyses shown these putative hub mutually densely interconnected, forming “rich club” within the brain. Here we show pathways linking rich club forms central high-cost, high-capacity backbone for global communication. Diffusion tensor imaging (DTI) data two sets 40 healthy subjects were used to map networks. The contributions network cost communication capacity cortico-cortical connections assessed through measures their topology spatial embedding. Rich found be more costly than predicted by density alone accounted 40% total cost. Furthermore, 69% all minimally short paths between node pairs travel large proportion consisted ordered sequences edges (“path motifs”) first fed into, then traversed, finally exited club, while passing nodes increasing decreasing degree. prevalence follow such degree suggests neural might take advantage strategies dynamic routing information regions, with an important role club. Taken together, our results make contribution interregional signal traffic,

参考文章(40)
M. P. van den Heuvel, O. Sporns, Rich-Club Organization of the Human Connectome The Journal of Neuroscience. ,vol. 31, pp. 15775- 15786 ,(2011) , 10.1523/JNEUROSCI.3539-11.2011
Cibu Thomas, Kate Humphreys, Kwan-Jin Jung, Nancy Minshew, Marlene Behrmann, The anatomy of the callosal and visual-association pathways in high-functioning autism: A DTI tractography study Cortex. ,vol. 47, pp. 863- 873 ,(2011) , 10.1016/J.CORTEX.2010.07.006
Saad Jbabdi, Heidi Johansen-Berg, Tractography - where do we go from here? Brain connectivity. ,vol. 1, pp. 169- 183 ,(2011) , 10.1089/BRAIN.2011.0033
O. Simsek, D. Jensen, Navigating networks by using homophily and degree Proceedings of the National Academy of Sciences of the United States of America. ,vol. 105, pp. 12758- 12762 ,(2008) , 10.1073/PNAS.0800497105
Olaf Sporns, Christopher J. Honey, Rolf Kötter, Identification and Classification of Hubs in Brain Networks PLoS ONE. ,vol. 2, pp. e1049- ,(2007) , 10.1371/JOURNAL.PONE.0001049
Marián Boguñá, Dmitri Krioukov, K. C. Claffy, Navigability of complex networks Nature Physics. ,vol. 5, pp. 74- 80 ,(2009) , 10.1038/NPHYS1130
Tore Opsahl, Vittoria Colizza, Pietro Panzarasa, José J Ramasco, None, Prominence and Control: The Weighted Rich-Club Effect Physical Review Letters. ,vol. 101, pp. 168702- ,(2008) , 10.1103/PHYSREVLETT.101.168702
Danielle S. Bassett, Jesse A. Brown, Vibhas Deshpande, Jean M. Carlson, Scott T. Grafton, Conserved and variable architecture of human white matter connectivity. NeuroImage. ,vol. 54, pp. 1262- 1279 ,(2011) , 10.1016/J.NEUROIMAGE.2010.09.006
The Organization of Neural Systems in the Primate Cerebral Cortex Proceedings of The Royal Society B: Biological Sciences. ,vol. 252, pp. 13- 18 ,(1993) , 10.1098/RSPB.1993.0040