作者: Martijn P Van Den Heuvel , René S Kahn , Joaquín Goñi , Olaf Sporns
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摘要: Network studies of human brain structural connectivity have identified a specific set regions that are both highly connected and central. Recent analyses shown these putative hub mutually densely interconnected, forming “rich club” within the brain. Here we show pathways linking rich club forms central high-cost, high-capacity backbone for global communication. Diffusion tensor imaging (DTI) data two sets 40 healthy subjects were used to map networks. The contributions network cost communication capacity cortico-cortical connections assessed through measures their topology spatial embedding. Rich found be more costly than predicted by density alone accounted 40% total cost. Furthermore, 69% all minimally short paths between node pairs travel large proportion consisted ordered sequences edges (“path motifs”) first fed into, then traversed, finally exited club, while passing nodes increasing decreasing degree. prevalence follow such degree suggests neural might take advantage strategies dynamic routing information regions, with an important role club. Taken together, our results make contribution interregional signal traffic,