Esters of Glucose-2-Phosphate: Occurrence and Chemistry

摘要: Phosphodiesters of glucose-2-phosphate (G2P) are found only in few natural compounds such as agrocinopine D and agrocin 84. Agrocinopine is a G2P phosphodiester produced by plants infected Agrobacterium fabrum C58 recognized the bacterial periplasmic binding protein AccA for being transported into bacteria before cleavage phosphodiesterase AccF, releasing G2P, which promotes virulence repressor AccR. The amide 84 antibiotic non-pathogenic radiobacter K84 strain used biocontrol agent competing with C58. esters also irregular glycogen structures. rare glucopyranosyl-2-phophoryl moiety key structural signature enabling its action antibiotic. Likewise, can dupe catabolism cascade. Such observations illustrate importance on we have recently focused our interest. After brief review reported phosphorylation coupling methods choice carbohydrate building blocks chemistry, flexible access to using phosphoramidite route proposed.