Novel cyclohexyl sulphones

作者: Ian Churcher , Kevin Dinnell , Sonia Kerrad , Susannah Williams , Brian Williams

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摘要: Novel sulphones of formula I are disclosed: The compounds modulate the processing amyloid precursor protein by gamma-secretase, and hence useful in treatment or prevention Alzheimer's disease.

参考文章(7)
Kevin Dinnell, Richard Alexander Jelley, Alan John Nadin, Duncan Edward Shaw, Karl Richard Gibson, Brian John Williams, Paul Joseph Oakley, Timothy Harrison, Andrew Pate Owens, Cyclohexyl sulphones as gamma-secretase inhibitors ,(2004)
Ian Churcher, Sonia Kerrad, Duncan Edward Shaw, Susannah Williams, Timothy Harrison, Paul Joseph Oakley, Martin Richard Teall, Cyclohexyl sulphone derivatives as gamma-secretase inhibitors ,(2003)
Paul Joseph Oakley, Martin Richard Teall, Timothy Harrison, Sulphones which modulate the action of gamma secretase ,(2001)
Michael A. Poss, Prasad Chaturvedula, Charles P. Sloan, Kevin Felsenstein, David W. Smith, 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of β-amyloid protein production ,(1996)