Secretory IgA's Complex Roles in Immunity and Mucosal Homeostasis in the Gut

摘要: Secretory IgA (SIgA) serves as the first line of defense in protecting intestinal epithelium from enteric toxins and pathogenic microorganisms. Through a process known immune exclusion, SIgA promotes clearance antigens microorganisms lumen by blocking their access to epithelial receptors, entrapping them mucus, facilitating removal peristaltic mucociliary activities. In addition, functions mucosal immunity homeostasis through mechanisms that have only recently been revealed. just past several years, has identified having capacity directly quench bacterial virulence factors, influence composition microbiota Fab-dependent Fab-independent mechanisms, promote retro-transport across dendritic cell subsets gut-associated lymphoid tissue, and, finally, downregulate proinflammatory responses normally associated with uptake highly bacteria potentially allergenic antigens. This review summarizes intrinsic biological activities now relationships homeostasis.