Tandem synthesis of quinazolinone scaffolds from 2-aminobenzonitriles using aliphatic alcohol–water system
作者： Bivas Chandra Roy , Sk. Abdus Samim , Dibyajyoti Panja , Sabuj Kundu
DOI: 10.1039/C9CY01094G
关键词:
摘要: Ru(II) complex catalyzed tandem synthesis of quinazolinone derivatives is reported here. In this sustainable protocol, 2-aminobenzonitriles were directly transformed to quinazolinones using alcohol–water system. A variety was successfully synthesized in good excellent yields by utilizing challenging methanol and aliphatic alcohols. The practical applicability the protocol extended preparative scale various heterocycles as well natural products. To understand mechanism several control experiments DFT studies carried out. Based on calculations, a metal–ligand cooperative proposed for
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