Physiological responses to maximal eating in men

摘要: This study investigated metabolic, endocrine, appetite and mood responses to a maximal eating occasion in fourteen men (mean: age 28 (sd 5) years, body mass 77·2 6·6) kg BMI 24·2 2·2) kg/m2) who completed two trials randomised crossover design. On each occasion, participants ate homogenous mixed-macronutrient meal (pizza). one they until 'comfortably full' (ad libitum) on the other, 'could not eat another bite' (maximal). Mean energy intake was double (13 024 (95 % CI 10 964, 15 084) kJ; 3113 2620, 3605) kcal) compared with ad libitum trial (6627 5708, 7547) 1584 1364, 1804) kcal). Serum insulin incremental AUC (iAUC) increased approximately 1·5-fold 43·8 28·3, 59·3) nmol/l × 240 min 67·7 47·0, 88·5) min, P < 0·01), but glucose iAUC did differ between 94·3 30·3, 158·2) mmol/l 126·5 76·9, 176·0) = 0·19). TAG greater v. 98·6 69·9, 127·2) 146·4 88·6, 204·1) 0·01). Total glucagon-like peptide-1, glucose-dependent insulinotropic peptide tyrosine-tyrosine were (P 0·05). ghrelin concentrations decreased similar extent, slightly lower 0·02). There marked differences trials, most notably caused prolonged increase lethargy. Healthy have capacity twice content required achieve comfortable fullness at single meal. Postprandial glycaemia is well regulated following initial overeating, elevated postprandial insulinaemia probably contributing.