Nonrandom Chromosomal Abnormalities in Acute Nonlymphocytic Leukemia in Patients Treated for Hodgkin Disease and Non-Hodgkin Lymphomas

摘要: Chromosomal analyses of myeloid cells were performed on ten patients who had acute nonlymphocytic leukemia (ANLL) following treatment for malignant lymphoma. Seven Hodgkin disease and three non-Hodgkin lymphoma, poorly differentiated lymphocytic type. Six treated with radiotherapy chemotherapy; two only, chemotherapy only. The median time between diagnosis lymphoma subsequent was 58 mo. Four the blast phase a myeloproliferative syndrome, four myelogenous leukemia, one promyelocytic tenth, erythroleukemia. None whose intensive responded. Every patient an abnormal karyotype. showed hypodiploid cell lines, pseudodiploid, hyperdiploid line. Cells from every except lacking B chromosome; in eight, this could be identified as No. 5. Five nine 7. Loss or rearrangement 17 found Nos. 6 8 patients. Many karyotypes bizarre, marker chromosomes minute chromosomes. karyotypic pattern seen these no correlation nature originalmore » type therapy used. chromosomal lines ANLL that arose de novo similar to occurring However, novo, less than half fewer 46 chromosomes, 10% 45 In study, 70% 40% critical question thus concerns factors, yet unknown, predispose development modal numbers lymphoma.« less