The development of a plant-based vaccine for measles.
作者： D.E. Webster , M.C. Thomas , Z Huang , S.L. Wesselingh
DOI: 10.1016/J.VACCINE.2004.11.018
关键词:
摘要: Plant-based vaccination strategies have the potential to overcome limitations of current measles vaccine. The virus hemagglutinin (MV-H) protein has been expressed in tobacco. Oral immunisation mice with plant-derived MV-H resulted MV-specific antibodies and secretory IgA, indicative humoral mucosal immune responses. In addition, boosting oral following a DNA prime, greater response than could be induced either vaccine alone. Collectively, this research represents significant step towards an effective that would temperature-stable, easy administer amenable inexpensive manufacture.
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