Association of Adiponectin with Adolescent Cardiovascular Health in a Dietary Intervention Study

摘要: Objective To investigate whether an infancy-onset, low saturated fat-oriented dietary intervention influences serum adiponectin concentration in adolescents, and to study the association of with subclinical markers vascular health, cardio-metabolic risk factors. Study design The longitudinal, randomized Special Turku Coronary Risk Factor Intervention Project aimed modify child's fat quality replacing unsaturated fat. Serum (n = 521) along weight, height, high-density lipoprotein cholesterol, C-reactive protein (CRP), triglycerides, insulin were measured at age 15 years. Adiposity was assessed using body mass index, waist circumference, abdominal thickness ultrasound. Metabolic syndrome defined according International Diabetes Foundation criteria. Vascular ultrasound measures including carotid intima-media (IMT) assessed. Results Adiponectin concentrations similar control groups ( P  = .16). associated IMT (r = −0.13,  = .005), cholesterol (r = 0.18,  = .0004), CRP (r = −0.10,  = .02), (r = −0.14,  = .002), adiposity (r = −0.18-0.24,  ≤ .0001). When adjusted for indices, only marginally diluted  = .03-.06), but associations became nonsignificant. Adolescents adiponectin ≤median had 4-fold metabolic than peers >median (CI 1.8-10.2,  = .0001). Conclusions In healthy is related syndrome. We found no evidence that repeated counseling would influence adolescence. Trial registration Registered ClinicalTrials.gov: NCT00223600.