Immunohistochemical expression of WT1 by desmoplastic small round cell tumor: a comparative study with other small round cell tumors.
作者： Raphaëlle Barnoud , Jean-Christophe Sabourin , Dominique Pasquier , Dominique Ranchère , Christiane Bailly
DOI: 10.1097/00000478-200006000-00008
关键词:
摘要: Desmoplastic small round cell tumors (DSRCTs) present a reciprocal chromosomal translocation, t(11;22)(p13;q12), that results in fusion of Ewing's sarcoma and Wilms' tumor (WT1) genes. The authors evaluated 15 DSRCTs 71 other often considered the differential diagnosis for immunoreactivity using polyclonal antibody directed against WT1 part chimeric protein resulting from this translocation. immunostaining was performed on paraffin material WT(C-19) after heat-antigen retrieval. All (15 15, 100%) demonstrated strong nuclear immunoreactivity. Ten 14 nephroblastomas (71%) disclosed WT1-positive nuclei accordance with staining reported by others, rare focal positivity detected two 17 rhabdomyosarcomas. not observed sarcoma/primitive neuroectodermal (zero 21, 0%), neuroblastomas 17, or rhabdoid kidney two, 0%). In nephroblastoma, DSRCT difficult: Clinical morphologic data are similar these entities. current study validates as useful marker to separate tumors.
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