Vaccines to Accelerate Malaria Elimination and Eventual Eradication.

摘要: Remarkable progress has been made in coordinated malaria control efforts with substantial reductions malaria-associated deaths and morbidity achieved through mass administration of drugs vector measures including distribution long-lasting insecticide-impregnated bednets indoor residual spraying. However, emerging resistance poses a significant threat to the sustainability these interventions. In this light, research community charged development highly efficacious vaccine complement existing elimination measures. As past 40 years investment goal attests, is no small feat. The parasite complex organism, exquisitely adapted for survival under hostile conditions within human mosquito hosts. Here we review current strategies accelerate potential novel innovative approaches design better understanding host-parasite interaction.