Serum components that bind to threat agents

摘要: Low molecular weight serum components (less than 10,000 m.w.), in vaccinated animals and a human subject who has been exposed to threat agent inadvertently, bound purified O-polysaccharide (OPS, polymer of formamido-mannose) candidate agent, such as Brucella suis 145 vaccine is disclosed. These formed loose reversible precipitin with OPS high-salt borate-buffered agarose gel the observed by capillary electrophoresis. By using modified electrophoresis, invention also discloses presence two larger components, one similar size that albumin resembles mannan-binding lectin, vaccine. An indirect method for identifying vaccination antibodies against Brucella-OPS-antibodies. ELISA, electrophoresis animal challenge studies showed high 30% control did not require vaccination. could have cross-reactive cross-protective antigens naturally.