Efficient organocatalysts derived from simple chiral acyclic amino acids in asymmetric catalysis

摘要: Chiral amino acids have played a key role in the development of organocatalysis from biomimetic concept to an independent methodology, together with metal catalysis and enzyme catalysis, comprising three major catalytic methodologies modern organic synthesis. As excellent pool for design organocatalysts, chiral two obvious advantages: ready availability usually affordable costs modular structures allowing facile tuning efficiency. Recently, bifunctional/multifunctional primary–secondary amines, tertiary amine–thioureas, aminophosphines easily prepared simple acyclic been developed as efficient organocatalysts various asymmetric reactions leading variety useful compounds. In this perspective, we present personal overview some these recent advances field based on our own research experience.