mTOR Pathway in Renal Cell Carcinoma
作者： Matteo Santoni , Francesco Massari
DOI: 10.1016/B978-0-12-802733-2.00026-8
关键词:
摘要: Abstract The therapeutic approach of patients with metastatic renal cell carcinoma (mRCC) has been completely changed by the advent agents targeting vascular endothelial growth factor receptor and mammalian target rapamycin (mTOR) pathway. employment mTOR inhibitors everolimus temsirolimus reported to improve outcome mRCC in different settings. Unfortunately, several mechanisms have shown be implicated development resistance inhibitors. Here we describe role pathway RCC metastasization. Furthermore, discuss as a this context associated drug resistance.
sci-hub.st 参考文章(92)
Yosra Messai, Muhammad Zaeem Noman, Bassam Janji, Meriem Hasmim, Bernard Escudier, Salem Chouaib, The autophagy sensor ITPR1 protects renal carcinoma cells from NK-mediated killing. Autophagy. pp. 0- ,(2015) , 10.1080/15548627.2015.1017194
Wilfred Lieberthal, Robert Fuhro, C. Christopher Andry, Helmut Rennke, Vivian E. Abernathy, Jason S. Koh, Robert Valeri, Jerrold S. Levine, Rapamycin impairs recovery from acute renal failure: role of cell-cycle arrest and apoptosis of tubular cells. American Journal of Physiology-renal Physiology. ,vol. 281, ,(2001) , 10.1152/AJPRENAL.2001.281.4.F693
Enrique Rozengurt, Thomas Seufferlein, Rapamycin Inhibits Constitutive p70s6k Phosphorylation, Cell Proliferation, and Colony Formation in Small Cell Lung Cancer Cells Cancer Research. ,vol. 56, pp. 3895- 3897 ,(1996)
Peter J. Houghton, Hajime Hosoi, Michael B. Dilling, Glen S. Germain, Lili Shu, Robert T. Abraham, Linda N. Liu, Takuma Shikata, Richard A. Ashmun, Rapamycin Causes Poorly Reversible Inhibition of mTOR and Induces p53-independent Apoptosis in Human Rhabdomyosarcoma Cells Cancer Research. ,vol. 59, pp. 886- 894 ,(1999)
Ainara Elorza, Inés Soro-Arnáiz, Florinda Meléndez-Rodríguez, Victoria Rodríguez-Vaello, Glenn Marsboom, Guillermo de Cárcer, Bárbara Acosta-Iborra, Lucas Albacete-Albacete, Angel Ordóñez, Leticia Serrano-Oviedo, Jose Miguel Giménez-Bachs, Alicia Vara-Vega, Antonio Salinas, Ricardo Sánchez-Prieto, Rafael Martín del Río, Francisco Sánchez-Madrid, Marcos Malumbres, Manuel O. Landázuri, Julián Aragonés, HIF2α Acts as an mTORC1 Activator through the Amino Acid Carrier SLC7A5 Molecular Cell. ,vol. 48, pp. 681- 691 ,(2012) , 10.1016/J.MOLCEL.2012.09.017
E HERVOUET, H SIMONNET, C GODINOT, Mitochondria and reactive oxygen species in renal cancer Biochimie. ,vol. 89, pp. 1080- 1088 ,(2007) , 10.1016/J.BIOCHI.2007.03.010
Camillo Porta, Cezary Szczylik, Bernard Escudier, Combination or sequencing strategies to improve the outcome of metastatic renal cell carcinoma patients: A critical review Critical Reviews in Oncology/Hematology. ,vol. 82, pp. 323- 337 ,(2012) , 10.1016/J.CRITREVONC.2011.06.001
Victor O. Okoh, Quentin Felty, Jai Parkash, Robert Poppiti, Deodutta Roy, Reactive oxygen species via redox signaling to PI3K/AKT pathway contribute to the malignant growth of 4-hydroxy estradiol-transformed mammary epithelial cells. PLOS ONE. ,vol. 8, ,(2013) , 10.1371/JOURNAL.PONE.0054206
Siming Li, Yan Kong, Lu Si, Zhihong Chi, Chuanliang Cui, Xinan Sheng, Jun Guo, Phosphorylation of mTOR and S6RP predicts the efficacy of everolimus in patients with metastatic renal cell carcinoma BMC Cancer. ,vol. 14, pp. 376- 376 ,(2014) , 10.1186/1471-2407-14-376
Brendan D. Manning, Lewis C. Cantley, AKT/PKB signaling: navigating downstream. Cell. ,vol. 129, pp. 1261- 1274 ,(2007) , 10.1016/J.CELL.2007.06.009