Small-molecule inhibitors of angiogenin and rnases and in vivo and in vitro methods of using same

摘要: Lead compounds were obtained in a high throughput screen (HTS) of angiogenin (ANG; potent inducer angiogenesis) enzyme activity, an RNase. One lead was shown to delay appearance tumors animal tumor system, and reduce the number animals having tumors. Several compound analogs found be even more inhibitors ANG activity compared original leads, two also have greater affinity for than pancreatic Other embodiments disclose method comprising obtaining ribonuclease inhibitor composition; admixing composition form admixture, wherein that may present admixture is inhibited.