A-beta binding polypeptides

作者: Cornelia Dorner-Ciossek , John E. Park , Katharina Zimmermann , Toon Laeremans , Gerald Beste

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摘要: The invention relates to biparatopic A-beta binding polypeptides and, more specifically, comprising at least two immunoglobulin single variable domains different epitopes of A-beta. also specific sequences such polypeptides, methods their production, and using them, including treatment diseases as Alzheimer's Disease.

参考文章(60)
Van Bockstaele F, Holz Jb, Revets H, The development of nanobodies for therapeutic applications. Current opinion in investigational drugs. ,vol. 10, pp. 1212- 1224 ,(2009)
Volker Germaschewski, Stephen Anthony Burbidge, Karen Louise Philpott, Peter Ernest Soden, Susannah K. Ford, Umesh Kumar, Jonathan Henry Ellis, Antibodies against amyloid-beta peptide ,(2007)
Andreas Schaubmar, Bernd Bohrmann, Hansruedi Loetscher, Hans Koll, Karl Weyer, Walter Huber, Kurt Lang, Diana Schuhbauer, Manfred Brockhaus, Antibodies Against Amyloid Beta 4 With Glycosylated in the Variable Region ,(2006)
J.F. Schildbach, R.I. Near, R.E. Bruccoleri, E Haber, P.D. Jeffrey, S.C. Ng, J Novotny, S Sheriff, M.N. Margolies, Heavy chain position 50 is a determinant of affinity and specificity for the anti-digoxin antibody 26-10 Journal of Biological Chemistry. ,vol. 268, pp. 21739- 21747 ,(1993) , 10.1016/S0021-9258(20)80605-X
Frédérique Bard, Catherine Cannon, Robin Barbour, Rae-Lyn Burke, Dora Games, Henry Grajeda, Teresa Guido, Kang Hu, Jiping Huang, Kelly Johnson-Wood, Karen Khan, Dora Kholodenko, Mike Lee, Ivan Lieberburg, Ruth Motter, Minh Nguyen, Ferdie Soriano, Nicki Vasquez, Kim Weiss, Brent Welch, Peter Seubert, Dale Schenk, Ted Yednock, Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nature Medicine. ,vol. 6, pp. 916- 919 ,(2000) , 10.1038/78682
Satoshi Saito, Masafumi Ihara, New therapeutic approaches for Alzheimer's disease and cerebral amyloid angiopathy Frontiers in Aging Neuroscience. ,vol. 6, pp. 290- 290 ,(2014) , 10.3389/FNAGI.2014.00290
Cornelia Dorner-Ciossek, John E. Park, Katharina Zimmermann, Toon Laeremans, Gerald Beste, Jo Vercammen, Pascal Merchiers, Martin Lenter, Lothar Kussmaul, Stefan Hoerer, Biparatopic abeta binding polypeptides ,(2011)
M N Margolies, L J Wysocki, B Parhami-Seren, P H Kussie, A single engineered amino acid substitution changes antibody fine specificity. Journal of Immunology. ,vol. 152, pp. 146- 152 ,(1994)
Maria Pihlgren, Andreas Muhs, Ryan J. Watts, Andrea Pfeifer, Monoclonal anti beta amyloid antibody ,(2008)