Process for the preparation of a pharmaceutical formulation containing at least two different active substances and use of such a formulation

作者: Gerhard Gergely , Wolfram Tritthart

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摘要: An aqueous solution or dispersion for oral intake of at least two different pharmaceutical active substances is prepared by dissolving suspending effervescent, soluble and/or disintegrating mixtures in tablet granule form, each which contains a substance combination, one and the same quantity water. At tablets may be used only as fragment, weigh less than 2000 mg, preferably 1500 particular 1000 mg. In diuretic, hydrochlorothiazide furosemide, further beta-blocker vasodilator, naftidrofuryl, calcium antagonist, ACE inhibitor alpha-1-blocker. Such form are treatment hypertension. Other combinations suitable asthma osteoporosis ulcer therapy.

参考文章(7)
Donald Lyons Martin, Pitambar Somani, Aminoalkyl sulfate esters with diuretic activity ,(1972)
Clarence L. Hancock, Lawrence J. Daher, Thomas A. Alexander, Donald L. Peterson, Method of preparing oral dosage forms with a granulating composition ,(1990)
Thomas Gergely, Irmgard Gergely, Gerhard Gergely, Disintegrating tablet and process for its preparation ,(1986)
Randall T. Sparks, Edward J. Geoghegan, Controlled release powder and process for its preparation ,(1988)