The risk of progression to invasive disease

摘要: Background Actinic keratoses occasionally progress to invasive skin cancer. The clinician-dermatologist ideally would like know which lesions are at individual risk. Various investigators have attempted answer this problem through a variety of clinical research applications including counting in populations risk, the general population, and by examining insurance claims data extrapolating incidence figures. Objective purpose study was ascertain range risks for progression actinic Results Five studies were reviewed that covered period from 1988 1998. Published risk squamous cell carcinoma ranged 0.025% 16% per year. Extrapolation these suggests rate ∼8% taken as an average among cited statistical rates reviewed. Conclusion Although statistically occurs low percentage (∼10%), clinician is over broad population does not aid determining factor lesion. Hence decision treat made on related factors such history persistence, age patient, discomfort, extent coexisting photodamage, tolerance morbidity therapy,