Vascular adhesion and transendothelial migration of eosinophil leukocytes.

摘要: Tissues respond to injury with inflammation in an effort protect and repair the damaged site. During inflammation, leukocytes typically accumulate response certain chemicals produced within tissue itself. The passage of through vascular lumen into tissues occurs several phases, including rolling, activation, firm adhesion, transendothelial migration, subendothelial migration. Although infiltration eosinophil is one most important aspects allergic inflammatory reactions, eosinophils also participate nonallergic inflammation. Eosinophil accumulation regulated not only by endothelial adhesion molecules, but interactions between molecules extracellular matrix elements. This review summarizes regulation leukocyte A better understanding recruitment responses may lead development novel therapeutics for chronic diseases.