A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

作者: B.-H. Ahn , H.-S. Kim , S. Song , I. H. Lee , J. Liu

DOI: 10.1073/PNAS.0803790105

关键词:

摘要: … of Sir2 extends the life span of yeast as well as several other … measure of mitochondrial number and GAPDH for protein load… tissue expression of Sirt3 by Western blotting, we used 50 μg …

参考文章(26)
Sandra Morais Cardoso, Cláudia Pereira, Catarina Resende Oliveira, Mitochondrial function is differentially affected upon oxidative stress. Free Radical Biology and Medicine. ,vol. 26, pp. 3- 13 ,(1999) , 10.1016/S0891-5849(98)00205-6
Björn Schwer, Brian J. North, Roy A. Frye, Melanie Ott, Eric Verdin, The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide–dependent deacetylase Journal of Cell Biology. ,vol. 158, pp. 647- 657 ,(2002) , 10.1083/JCB.200205057
X. Yang, C. Li, X. Xu, C. Deng, The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 3667- 3672 ,(1998) , 10.1073/PNAS.95.7.3667
Heidi A. Tissenbaum, Leonard Guarente, Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans Nature. ,vol. 410, pp. 227- 230 ,(2001) , 10.1038/35065638
Tong Shi, Fei Wang, Emily Stieren, Qiang Tong, SIRT3, a Mitochondrial Sirtuin Deacetylase, Regulates Mitochondrial Function and Thermogenesis in Brown Adipocytes Journal of Biological Chemistry. ,vol. 280, pp. 13560- 13567 ,(2005) , 10.1074/JBC.M414670200
Christian Cortés-Rojo, Elizabeth Calderón-Cortés, Mónica Clemente-Guerrero, Salvador Manzo-Ávalos, Salvador Uribe, Istvan Boldogh, Alfredo Saavedra-Molina, Electron transport chain of Saccharomyces cerevisiae mitochondria is inhibited by H2O2 at succinate-cytochrome c oxidoreductase level without lipid peroxidation involvement. Free Radical Research. ,vol. 41, pp. 1212- 1223 ,(2007) , 10.1080/10715760701635082
Jianyuan Luo, Anatoly Y. Nikolaev, Shin-ichiro Imai, Delin Chen, Fei Su, Ariel Shiloh, Leonard Guarente, Wei Gu, Negative Control of p53 by Sir2α Promotes Cell Survival under Stress Cell. ,vol. 107, pp. 137- 148 ,(2001) , 10.1016/S0092-8674(01)00524-4
Sung Chan Kim, Robert Sprung, Yue Chen, Yingda Xu, Haydn Ball, Jimin Pei, Tzuling Cheng, Yoonjung Kho, Hao Xiao, Lin Xiao, Nick V. Grishin, Michael White, Xiang-Jiao Yang, Yingming Zhao, Substrate and Functional Diversity of Lysine Acetylation Revealed by a Proteomics Survey Molecular Cell. ,vol. 23, pp. 607- 618 ,(2006) , 10.1016/J.MOLCEL.2006.06.026
P. Onyango, I. Celic, J. M. McCaffery, J. D. Boeke, A. P. Feinberg, SIRT3, a human SIR2 homologue, is an NAD- dependent deacetylase localized to mitochondria Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 13653- 13658 ,(2002) , 10.1073/PNAS.222538099
James Murray, Sky Yonally, Robert Aggeler, Michael F. Marusich, Roderick A. Capaldi, Focused proteomics: towards a high throughput monoclonal antibody-based resolution of proteins for diagnosis of mitochondrial diseases. Biochimica et Biophysica Acta. ,vol. 1659, pp. 206- 211 ,(2004) , 10.1016/J.BBABIO.2004.07.005