The beta-chain of the IL-2 receptor (p70) is tyrosine-phosphorylated on YT and HUT-102B2 cells.

摘要: IL-2 has previously been shown to rapidly induce activity of a tyrosine kinase. High-affinity receptors that mediate the major mitogenic signals contain both p70 and p55 chains. no potential phosphorylation sites lacks consensus sequences found in protein kinases. Inasmuch as hormone is generally an important mechanism for regulating receptor function, we have now investigated status p70. By using anti-phosphotyrosine antibodies immunoprecipitate affinity-labeled probe Western blots, provide data suggesting p70, but not p55, constitutively tyrosine-phosphorylated on leukemic cell lines studied.