cDNA expressed sequence tags of Trypanosoma brucei rhodesiense provide new insights into the biology of the parasite.
作者： Najib M.A. El-Sayed , Clara M. Alarcon , John C. Beck , Val C. Sheffield , John E. Donelson
DOI: 10.1016/0166-6851(95)00098-L
关键词:
摘要: A total of 518 expressed sequence tags (ESTs) have been generated from clones randomly selected a cDNA library and spliced leader sub-library Trypanosoma brucei rhodesiense bloodstream clone. 205 (39%) the were identified based on matches to 113 unique genes in public databases. Of these, 71 cDNAs display significant similarities unrelated organisms encoding metabolic enzymes, signal transduction proteins, transcription factors, ribosomal histones, proliferation-associated protein thimet oligopeptidase, among others. 313 are not related any other sequences These ESTs provide new avenues research for exploring both novel trypanosome-specific genome organization this parasite, as well resource identifying trypanosome homologs organisms.
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