Mononuclear CuII−Phenolate Bioinspired Complex is Catalytically Promiscuous: Phosphodiester and Peptide Amide Bond Cleavage
作者： Mauricio C. Bof Oliveira , Deise Mazera , Marciela Scarpellini , Patricia Cardoso Severino , Ademir Neves
DOI: 10.1021/IC802208V
关键词:
摘要: In this work, the cleavage activity of metal complex [Cu(C(21)H(21)N(3)O(2))(OH(2))(2)](2+) is demonstrated to occur toward double-stranded DNA, in addition its previously described amide bond activity, thus suggesting catalytic promiscuity for complex.
sci-hub.se 参考文章(31)
A HOPKINS, J MASON, J OVERINGTON, Can we rationally design promiscuous drugs Current Opinion in Structural Biology. ,vol. 16, pp. 127- 136 ,(2006) , 10.1016/J.SBI.2006.01.013
Monica Baldini, Marisa Belicchi-Ferrari, Franco Bisceglie, Giorgio Pelosi, Silvana Pinelli, Pieralberto Tarasconi, Cu(II) complexes with heterocyclic substituted thiosemicarbazones: the case of 5-formyluracil. Synthesis, characterization, x-ray structures, DNA interaction studies, and biological activity. Inorganic Chemistry. ,vol. 42, pp. 2049- 2055 ,(2003) , 10.1021/IC026131D
Marciela Scarpellini, Ademir Neves, Rosmari Hörner, Adailton J. Bortoluzzi, Bruno Szpoganics, César Zucco, René A. Nome Silva, Valderes Drago, Antônio S. Mangrich, Wilson A. Ortiz, Wagner A. C. Passos, Maurício C. B. de Oliveira, Hernán Terenzi, Phosphate diester hydrolysis and DNA damage promoted by new cis-aqua/hydroxy copper(II) complexes containing tridentate imidazole-rich ligands. Inorganic Chemistry. ,vol. 42, pp. 8353- 8365 ,(2003) , 10.1021/IC026277C
Changlin Liu, Li Wang, DNA hydrolytic cleavage catalyzed by synthetic multinuclear metallonucleases Dalton Trans.. pp. 227- 239 ,(2009) , 10.1039/B811616D
Xi Zhang, Alejandro Crespo, Ariel Fernández, Turning promiscuous kinase inhibitors into safer drugs Trends in Biotechnology. ,vol. 26, pp. 295- 301 ,(2008) , 10.1016/J.TIBTECH.2008.02.008
Nicolás A. Rey, Ademir Neves, Adailton J. Bortoluzzi, Claus T. Pich, Hernán Terenzi, Catalytic Promiscuity in Biomimetic Systems: Catecholase-like Activity, Phosphatase-like Activity, and Hydrolytic DNA Cleavage Promoted by a New Dicopper(II) Hydroxo-Bridged Complex Inorganic Chemistry. ,vol. 46, pp. 348- 350 ,(2007) , 10.1021/IC0613107
Pin Yang, Weijuan Zheng, Zichun Hua, A simple copper(II)-L-histidine system for efficient hydrolytic cleavage of DNA. Inorganic Chemistry. ,vol. 39, pp. 5454- 5463 ,(2000) , 10.1021/IC0000146
M.C.B. Oliveira, M.S.R. Couto, P.C. Severino, T. Foppa, G.T.S. Martins, B. Szpoganicz, R.A. Peralta, A. Neves, H. Terenzi, Nucleic acid cleavage by a Cu(II) polyaza macrocyclic complex Polyhedron. ,vol. 24, pp. 495- 499 ,(2005) , 10.1016/J.POLY.2004.12.016
Lucía Otero, Pablo Smircich, Marisol Vieites, Martín Ciganda, Patricia Cardoso Severino, Hernán Terenzi, Hugo Cerecetto, Dinorah Gambino, Beatriz Garat, DNA conformational changes and cleavage by ruthenium(II) nitrofurylsemicarbazone complexes. Journal of Inorganic Biochemistry. ,vol. 101, pp. 74- 79 ,(2007) , 10.1016/J.JINORGBIO.2006.08.004
Eric L. Hegg, Judith N. Burstyn, COPPER(II) MACROCYCLES CLEAVE SINGLE-STRANDED AND DOUBLE-STRANDED DNA UNDER BOTH AEROBIC AND ANAEROBIC CONDITIONS Inorganic Chemistry. ,vol. 35, pp. 7474- 7481 ,(1996) , 10.1021/IC960384N