Puerarin promotes ABCA1-mediated cholesterol efflux and decreases cellular lipid accumulation in THP-1 macrophages

作者: Cong-hui Li , Duo Gong , Ling-yan Chen , Min Zhang , Xiao-dan Xia

DOI: 10.1016/J.EJPHAR.2017.05.055

关键词:

摘要: … whether puerarin decreased lipid accumulation via up-regulation of ABCA1-mediated cholesterol efflux in THP-1 macrophage-derived foam cells. Our results showed that puerarin …

参考文章(48)
Mengmeng Yin, Yin Yuan, Yurong Cui, Xian Hong, Hongyan Luo, Xinwu Hu, Ming Tang, Jurgen Hescheler, Jiaoya Xi, Puerarin Suppresses the Self-Renewal of Murine Embryonic Stem Cells by Inhibition of REST-MiR-21 Regulatory Pathway. Cellular Physiology and Biochemistry. ,vol. 37, pp. 527- 536 ,(2015) , 10.1159/000430374
Michael C. Phillips, Molecular Mechanisms of Cellular Cholesterol Efflux Journal of Biological Chemistry. ,vol. 289, pp. 24020- 24029 ,(2014) , 10.1074/JBC.R114.583658
Yan-Wei Hu, Jia-Yi Zhao, Shu-Fen Li, Qian Wang, Lei Zheng, Genome-wide profiling to analyze the effects of Ox-LDL induced THP-1 macrophage-derived foam cells on gene expression. Genomics data. ,vol. 2, pp. 328- 331 ,(2014) , 10.1016/J.GDATA.2014.09.011
Xin Ma, Shu-Fen Li, Zai-Sheng Qin, Jing Ye, Zhen-Long Zhao, Hai-Hong Fang, Zhi-Wen Yao, Miao-Ning Gu, Yan-Wei Hu, Propofol up-regulates expression of ABCA1, ABCG1, and SR-B1 through the PPARγ/LXRα signaling pathway in THP-1 macrophage-derived foam cells. Cardiovascular Pathology. ,vol. 24, pp. 230- 235 ,(2015) , 10.1016/J.CARPATH.2014.12.004
Hideki Ozasa, Makoto Ayaori, Maki Iizuka, Yoshio Terao, Harumi Uto-Kondo, Emi Yakushiji, Shunichi Takiguchi, Kazuhiro Nakaya, Tetsuya Hisada, Yoshinari Uehara, Masatsune Ogura, Makoto Sasaki, Tomohiro Komatsu, Shunpei Horii, Seibu Mochizuki, Michihiro Yoshimura, Katsunori Ikewaki, Pioglitazone enhances cholesterol efflux from macrophages by increasing ABCA1/ABCG1 expressions via PPARγ/LXRα pathway: Findings from in vitro and ex vivo studies Atherosclerosis. ,vol. 219, pp. 141- 150 ,(2011) , 10.1016/J.ATHEROSCLEROSIS.2011.07.113
Feng Tian, Li-Hui Xu, Wei Zhao, Li-Jie Tian, Xiang-Lu Ji, The optimal therapeutic timing and mechanism of puerarin treatment of spinal cord ischemia-reperfusion injury in rats. Journal of Ethnopharmacology. ,vol. 134, pp. 892- 896 ,(2011) , 10.1016/J.JEP.2011.01.055
Isabelle Gerin, Laure-Alix Clerbaux, Olivier Haumont, Nicolas Lanthier, Arun K. Das, Charles F. Burant, Isabelle A. Leclercq, Ormond A. MacDougald, Guido T. Bommer, Expression of miR-33 from an SREBP2 Intron Inhibits Cholesterol Export and Fatty Acid Oxidation, Journal of Biological Chemistry. ,vol. 285, pp. 33652- 33661 ,(2010) , 10.1074/JBC.M110.152090
Shu-Yong WEI, Yi CHEN, Xiao-Yu XU, Progress on the pharmacological research of puerarin: a review. Chinese Journal of Natural Medicines. ,vol. 12, pp. 407- 414 ,(2014) , 10.1016/S1875-5364(14)60064-9
Denis O. Sviridov, Alexander M. Andrianov, Ivan V. Anishchenko, John A. Stonik, Marcelo J. A. Amar, Scott Turner, Alan T. Remaley, Hydrophobic Amino Acids in the Hinge Region of the 5A Apolipoprotein Mimetic Peptide are Essential for Promoting Cholesterol Efflux by the ABCA1 Transporter Journal of Pharmacology and Experimental Therapeutics. ,vol. 344, pp. 50- 58 ,(2013) , 10.1124/JPET.112.198143