Changes in midbrain serotonin transporter availability in atypically depressed subjects after one year of psychotherapy.
作者： Soili M. Lehto , Tommi Tolmunen , Mikko Joensuu , Pirjo I. Saarinen , Minna Valkonen-Korhonen
DOI: 10.1016/J.PNPBP.2007.08.013
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摘要: Abstract Background Psychotherapy is an effective treatment method for depression, but no differences in the psychotherapy response have been found between subtypes of depression. The effect on neurotransmitter transporter functions has never recorded depressed subjects. Methods Depressive outpatients ( N = 19) received psychodynamic 12 months. All subjects fulfilled DSM-IV criteria and 8 were classified as having atypical severity depression was assessed with 29-item Hamilton Depression Rating Scale (HAM-D-29). Midbrain serotonin (SERT) striatum dopamine (DAT) densities using single photon emission computed tomography (SPECT) brain imaging [ 123 I]nor-β-CIT radioligand before after psychotherapy. Results SERT density significantly increased during atypicals not nonatypicals. There changes levels DAT. Conclusions psychotherapy-related elevation atypically may be due to some unknown adaptive mechanisms inducing increase either or serotonergic nerve terminals therefore enhancing activity improving mood.
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