Synthesis of thienopyridinones via hydrazide-alkyne cyclization
作者： Nalan Korkmaz Cokol , Kübra Erden , Furkan Melih Gunay , Cagatay Dengiz , Metin Balci
DOI: 10.1016/J.TET.2020.131151
关键词:
摘要: Abstract A novel and efficient method for the synthesis of thieno[3,2-c]pyridinones have been developed. The synthetic strategy relies on halothiophene esters utilized as substrates subsequent Sonogashira cross-coupling reactions. Hydrazinolysis corresponding following hydrazide-alkyne ring closure transformations resulted in target thienopyridinones good yields. It is also shown that pure hydrazine monohydrate required to facilitate hydrazide formations.
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