A Modification of Simon's Optimal Design for Phase II Trials When the Criterion Is Median Sample Size
作者： John J. Hanfelt , Rebecca S. Slack , Edmund A. Gehan
DOI: 10.1016/S0197-2456(99)00028-8
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摘要: Abstract We present a modification to Simon's optimal design for phase II trials in which the objective is minimize median sample size rather than expected when true response rate poor p = 0 . argue that modified may be preferred smaller institutions focus on single or small number of large program trials. Control Clin Trials 1999;20:555–566
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