Propionyl-L-carnitine limits chronic ventricular dilation after myocardial infarction in rats.

摘要: To determine whether propionyl-L-carnitine (PLC) administration ameliorates ventricular remodeling after myocardial infarction, we performed coronary occlusion in rats and examined the long-term effects of drug 19-24 wk surgery. In view well-established role angiotensin-converting enzyme (ACE) inhibitors reduction dilation therapeutic impact oral PLC (60 mg/kg) was compared with that enalapril (1 mg/kg). Infarct size measured planimetrically found to be comparable untreated, PLC-treated, enalapril-treated rats, averaging 40-46% left free wall. Heart weight increased 14, 16, 11% no treatment, PLC, enalapril, respectively. The relationship between filling pressure chamber volume demonstrated significantly prevented expansion cavitary infarction. These protective influences were observed throughout range pressures measured, from 0 30 mmHg. At a uniform reference point 4 mmHg, untreated infarcted hearts showed an 2.17-fold (P < 0.0001). Corresponding increases this parameter 36 43%, respectively, both not statistically significant. Moreover, capable reducing alterations compliance associated conclusion, reduces magnitude decompensated eccentric hypertrophy produced by infarction manner similar ACE inhibition.