The MatTek story - how the three Rs principles led to 3-D tissue success!

摘要: MatTek Corporation has been working diligently for over 15 years to replace traditional animal-based toxicity and efficacy tests with alternative test methods based on human-cell derived, three-dimensional (3-D) tissue models. First discussed in detail by W.M.S. Russell R.L. Burch 50 ago their book, The Principles of Humane Experimental Technique, now fully integrated into forward-looking publications such as Toxicity Testing the 21st Century: A Vision a Strategy, concept replacing animals procedures human cells and/or cell-derived vitro 3-D tissues is being embraced world's research scientists toxicologists at an ever-increasing rate. models are utilised not only humanitarian reasons, but also because tissues, particular, produce more-physiologically relevant scientific data. Early MatTek's efforts develop this method, senior management sought assistance experts within testing animal rights communities, help define specific products needed navigate regulatory landscape, especially Europe where replacement non-animal was well underway. fortunate receive that expert both fronts from Professor Michael Balls, who time newly-elected first director ECVAM. In 1997, guidance support Balls others community, began effort validate several its tissue-based methods. Today, two validated full replacements existing tests, more validation pipeline. addition, use worldwide chemical, pharmaceutical consumer product companies, evidenced citations hundreds patents articles these industries. This article concludes thoughts direction will take future.