Versatile multicompartment nanoparticles constructed with two thermo-responsive, pH-responsive and hydrolytic diblock copolymers

作者: Shengli Chen , Xueying Chang , Pingchuan Sun , Wangqing Zhang

DOI: 10.1039/C7PY01182B

关键词:

摘要: Multicompartment block copolymer nanoparticles (MCBNs) constructed with a thermo-responsive and base-sensitive poly(N-acryloylsarcosine methyl ester)-block-polystyrene (PNASME-b-PS) pH-responsive poly(4-vinylpyridine)-block-polystyrene (P4VP-b-PS) are synthesized by dispersion RAFT polymerization employing two macro-RAFT agents. These MCBNs contain hydrophobic polystyrene (PS) core dispersed microdomains formed either the poly(4-vinylpyridine) (P4VP) and/or ester) (PNASME). By changing degree of PS block, molar ratio diblock copolymers, temperature, pH, tuning interaction between acidic poly(N-acryloylsarcosine) obtained from hydrolysis PNASME alkaline P4VP convenient size morphology is achieved, well-defined including several different microdomains, core–corona particles shell-bonded core–shell have been prepared.

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