Determination of aflatoxin M1 in ice cream samples using immunoaffinity columns and ultra-high performance liquid chromatography coupled to tandem mass spectrometry
作者： Duvan Esteban Hoyos Ossa , Diego Alfonso Hincapié , Gustavo Antonio Peñuela , None
DOI: 10.1016/J.FOODCONT.2015.03.011
关键词:
摘要: Abstract In this work, a highly sensitive method was developed for the selective determination of aflatoxin M1 mycotoxin in ice cream samples using ultra high performance liquid chromatography–tandem mass spectrometry (UHPLC-MS/MS). The low detection values required, μg/kg, made necessary sample concentration and cleaning targeted immunoaffinity columns compound after extraction from matrix phosphate buffered saline solution (PBS). Method validation carried out by means recovery experiments fortified near to lower end calibration curve higher level. All recoveries were found range 70–120 % with RSD less than 25%. Quantitation performed external standards prepared mobile phase. Validated used determine content AFM1 bought local stores. Compound identification quantitation/qualification ratios monitored transitions (Q/q1 Q/q2).
elsevier.com
sci-hub.se 参考文章(12)
Hussein S Hussein, Jeffrey M Brasel, Toxicity, metabolism, and impact of mycotoxins on humans and animals. Toxicology. ,vol. 167, pp. 101- 134 ,(2001) , 10.1016/S0300-483X(01)00471-1
Vinod Kumar, M.S. Basu, T.P. Rajendran, Mycotoxin research and mycoflora in some commercially important agricultural commodities Crop Protection. ,vol. 27, pp. 891- 905 ,(2008) , 10.1016/J.CROPRO.2007.12.011
Michael E. Swartz, UPLC™: An Introduction and Review Journal of Liquid Chromatography & Related Technologies. ,vol. 28, pp. 1253- 1263 ,(2005) , 10.1081/JLC-200053046
Shahzad Zafar Iqbal, Muhammad Rafique Asi, S. Jinap, Variation of aflatoxin M1 contamination in milk and milk products collected during winter and summer seasons Food Control. ,vol. 34, pp. 714- 718 ,(2013) , 10.1016/J.FOODCONT.2013.06.009
M. M. Aguilera-Luiz, P. Plaza-Bolaños, R. Romero-González, J. L. Martínez Vidal, A. Garrido Frenich, Comparison of the efficiency of different extraction methods for the simultaneous determination of mycotoxins and pesticides in milk samples by ultra high-performance liquid chromatography-tandem mass spectrometry Analytical and Bioanalytical Chemistry. ,vol. 399, pp. 2863- 2875 ,(2011) , 10.1007/S00216-011-4670-7
SL Costa Ferreira, RE Bruns, Hadla Sousa Ferreira, Geraldo Domingues Matos, JM David, GC Brandão, EG Paranhos da Silva, LA Portugal, PS Dos Reis, AS Souza, WNL Dos Santos, None, Box-Behnken design: An alternative for the optimization of analytical methods Analytica Chimica Acta. ,vol. 597, pp. 179- 186 ,(2007) , 10.1016/J.ACA.2007.07.011
Eduardo Beltrán, María Ibáñez, Juan Vicente Sancho, Miguel Ángel Cortés, Vicent Yusà, Félix Hernández, UHPLC–MS/MS highly sensitive determination of aflatoxins, the aflatoxin metabolite M1 and ochratoxin A in baby food and milk Food Chemistry. ,vol. 126, pp. 737- 744 ,(2011) , 10.1016/J.FOODCHEM.2010.11.056
Pieter S. Steyn, Mycotoxins, general view, chemistry and structure. Toxicology Letters. pp. 843- 851 ,(1995) , 10.1016/0378-4274(95)03525-7
Aziz A. Fallah, Aflatoxin M1 contamination in dairy products marketed in Iran during winter and summer Food Control. ,vol. 21, pp. 1478- 1481 ,(2010) , 10.1016/J.FOODCONT.2010.04.017
A. Prandini, G. Tansini, S. Sigolo, L. Filippi, M. Laporta, G. Piva, On the occurrence of aflatoxin M1 in milk and dairy products Food and Chemical Toxicology. ,vol. 47, pp. 984- 991 ,(2009) , 10.1016/J.FCT.2007.10.005