Premature mortality due to cardiovascular disease in hypopituitarism.

摘要: 333 consecutive patients with hypopituitarism diagnosed between 1956 and 1987 were retrospectively examined. The had been given routine replacement therapy. overall mortality was higher than in an age sex matched population. Deaths from vascular disorders also significantly increased (60 [40 male, 20 female] versus 30.8 expected [23.5, 7.4 female]). hazard function for death independent of at diagnosis, time after calendar year gender, degree pituitary insufficiency, hypertension, diabetes mellitus. Mortality risk raised irrespective whether due to adenoma or secondary other diseases. 7 (3 4 female) died malignant diseases (expected 10.1 4.1, respectively). These observations indicate that life expectancy is shortened hypopituitarism. Growth-hormone deficiency could be a factor this cardiovascular disease.