Comparison of Endogenous TP53 Genomic Status with Clonogenicity and Different Modes of Cell Death after X Irradiation
作者： Juxian Lu-Hesselmann , Michael Abend , Dirk van Beuningen
DOI: 10.1667/RR3092
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摘要: Abstract Lu-Hesselmann, J., Abend, M. and van Beuningen, D. Comparison of Endogenous TP53 Genomic Status with Clonogenicity Different Modes Cell Death after X Irradiation. Radiat. Res. 161, 39–47 (2004). Although extensive data indicate that the tumor suppressor modifies radiation responses human rodent cells, exact relationship between responsiveness remains controversial. To elucidate relevance endogenous genomic status to radiosensitivity in a cell-type-independent manner, different cells 10 cell lines tissues origin were examined for status. The was compared radiation-related survival parameters (Dq, D0, SF2) mode death. modes death by measuring radiation-induced micronucleation, apoptosis abnormal cells. Alterations gene detected eight lines. No splicing mutation found. Five showed codon 6...
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